Article

Abnormal neuronal and synaptic morphology in Down syndrome brains reproduces in human isogenic cellular models

2026-01-10

Abstract excerpt

Down syndrome (DS) is the most common autosomal aneuploidy compatible with postnatal survival and is caused by full or partial trisomy of chromosome 21. In this study, human isogenic induced pluripotent stem cells (iPSCs) were differentiated into 2D neurons and cortico-striatal assembloids (hCSAs). Abnormal neuronal morphology was observed: trisomic (T21) neurons formed aggregates of cell bodies interconnected wit...

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Literature Corpus work: f43d38aa-925c-5005-815a-6db011b44f66
DOI: 10.64898/2026.01.10.698781

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