Article
Epigenomic Consequences of Coding and Noncoding Driver Mutations.
Trends in cancer - 1 Oct 2016
Yao Xiaosai, Xing Manjie, Ooi Wen Fong, Tan Patrick, Teh Bin Tean
Abstract excerpt
Chromatin alterations are integral to the pathogenic process of cancer, as demonstrated by recent discoveries of frequent mutations in chromatin-modifier genes and aberrant DNA methylation states in different cancer types. Progress is being made on elucidating how chromatin alterations, and how proteins catalyzing these alterations, mechanistically contribute to tissue-specific tumorigenesis. In parallel,...
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