Article

CTNND2 regulation by the SRGAP2 protein family links human evolution to synaptic neoteny

2022-09-14

Abstract excerpt

<h4>SUMMARY</h4> Human-specific genes are potential drivers of brain evolution. Among them, SRGAP2C has contributed to the emergence of features characterizing human cortical synapses, including their extended period of maturation. SRGAP2C inhibits its ancestral copy, the postsynaptic protein SRGAP2A; yet the synaptic molecular pathways differentially regulated in humans by SRGAP2 proteins remain largely unknown....

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Literature Corpus work: fd4278fd-1c4f-5ee4-a75b-cd0b9fcff966
DOI: 10.1101/2022.09.13.507776

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