Article

A cross-species proteomic map reveals neoteny of human synapse development

2022-10-25

Abstract excerpt

The molecular mechanisms and evolutionary changes accompanying synapse development are still poorly understood. Here, we generated a cross-species proteomic map of synapse development in the human, macaque, and mouse neocortex. By tracking the changes of >1,000 postsynaptic density (PSD) proteins from midgestation to young adulthood, we found that PSD maturation in humans separates into three major phases that are...

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Literature Corpus work: 31f3792d-9ad6-5326-902f-e1d18bdd9000
DOI: 10.1101/2022.10.24.513541

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