Article
Context-dependent selection as the keystone in somatic evolution of cancer
2019-02-06
Abstract excerpt
Somatic evolution of cancer involves a series of mutations, and attendant changes, in one or more clones of cells. A "bad luck" type model assumes chance accumulation of mutations. The clonal expansion model assumes, on the other hand, that any mutation leading to partial loss of regulation of cell proliferation will give a selective advantage to the mutant. However, a number of experiments show that an intermedia...
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Identifiers and source
- Literature Corpus work
- e230b938-e5ca-59b7-9548-26570dbbce32
- DOI
- 10.1101/542290