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The Ecology and Evolution of Cancer: The Ultra-Microevolutionary Process.

Annual review of genetics - 23 Nov 2016

Wu Chung-I, Wang Hurng-Yi, Ling Shaoping, Lu Xuemei

Abstract excerpt

Although tumorigenesis has been accepted as an evolutionary process ( 20 , 102 ), many forces may operate differently in cancers than in organisms, as they evolve at vastly different time scales. Among such forces, natural selection, here defined as differential cellular proliferation among distinct somatic cell genotypes, is particularly interesting because its action might be thwarted in multicellular organisms...

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PMID: 27686281
DOI: 10.1146/annurev-genet-112414-054842

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