Article

Detection of prodromal Parkinson’s disease using a urine proteomics panel and machine learning

2023-09-15

Abstract excerpt

Parkinson’s disease is a progressive neurodegenerative disorder and idiopathic REM-sleep behaviour disorder (iRBD) has been identified as its single most specific early symptom. To facilitate the screening of individuals at high risk to develop Parkinson’s disease, we developed a multiplexed panel of urine proteomics using machine learning and targeted mass spectrometry to detect iRBD. Random urine samples from cl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e226e18a-a3d5-500b-aba7-62e36ed75657
DOI: 10.1101/2023.09.14.23295447

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Detection of prodromal Parkinson’s disease using a urine proteomics panel and machine learningDOI 10.1101/2023.09.14.23295447Read

Changes in the cerebrospinal fluid proteome precede and stratify the course of Parkinson’s DiseaseSemantic proximity Read

Orthogonal validation of PD Biomarkers: Multi-platform proteomics profiling of CSF, Plasma, and Urine confirms DDC as a consistent candidateSemantic proximity Read

Urinary proteome profiling for stratifying patients with familial Parkinson’s diseaseSemantic proximity Read

Urinary proteome profiling for stratifying patients with familial Parkinson's disease.Semantic proximity Read

High-Throughput CSF Proteomics and Machine Learning to Identify Proteomic Signatures for Parkinson Disease Development and ProgressionSemantic proximity Read

Proteome profiling of cerebrospinal fluid reveals biomarker candidates for Parkinson’s diseaseSemantic proximity Read

Machine learning -driven discovery of Parkinsonian-like phenotypes in idiopathic REM sleep behavior disorder.Semantic proximity Read

Discovery and validation of biomarkers for Parkinson’s disease from human cerebrospinal fluid using mass spectrometry-based proteomics analysisSemantic proximity Read

Sex-Stratified Multi-Omics Identifies Sexually Dimorphic Molecular Targets in Parkinson’s DiseaseSemantic proximity Read

A proteogenomic view of Parkinson’s disease causality and heterogeneitySemantic proximity Read

Parkinson’s disease causality and heterogeneity: a proteogenomic viewSemantic proximity Read

Identification of a possible proteomic biomarker in Parkinson’s disease: discovery and replication in blood, brain and cerebrospinal fluidSemantic proximity Read