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Discovery and validation of biomarkers for Parkinson’s disease from human cerebrospinal fluid using mass spectrometry-based proteomics analysis

1 Aug 2025

Abstract excerpt

BACKGROUND: Proteomic biomarkers for Parkinson's disease (PD) are critical for identifying new targets for disease-modifying therapies and expanding our understanding of disease pathophysiology. METHODS: Deep proteome analysis of a cerebrospinal fluid (CSF) cohort (40 PD, 40 controls) coupled with previous data from the substantia nigra (SN) proteome was used to discover low abundance biomarkers involved in PD...

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PMID: 40753721
DOI: 10.1016/j.ebiom.2025.105844

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