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A proteogenomic view of Parkinson’s disease causality and heterogeneity

11 Feb 2023

Abstract excerpt

The pathogenesis and clinical heterogeneity of Parkinson's disease (PD) have been evaluated from molecular, pathophysiological, and clinical perspectives. High-throughput proteomic analysis of cerebrospinal fluid (CSF) opened new opportunities for scrutinizing this heterogeneity. To date, this is the most comprehensive CSF-based proteomics profiling study in PD with 569 patients (350 idiopathic patients, 65 GBA +...

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PMID: 36774388
DOI: 10.1038/s41531-023-00461-9

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