Article

RNA interference mediates RNA toxicity with parent-of-origin effects in <i>C. elegans</i> expressing CTG repeats

2021-05-19

Abstract excerpt

Nucleotide repeat expansions are a hallmark of over 40 neurodegenerative diseases. These repeats cause RNA toxicity and trigger multisystemic symptoms that worsen with age. RNA toxicity can trigger, through an unclear mechanism, severe disease manifestation in infants that inherited repeats from their mothers. Here we show in Caenorhabditis elegans how RNA interference machinery causes intergenerational toxicity...

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Literature Corpus work: e220951b-1e0d-5938-ad12-e580e2e39949
DOI: 10.1101/2021.05.19.444826

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