Article

RNA nucleotide repeats induce mitochondrial dysfunction and the ribosome-associated quality control

2021-09-24

Abstract excerpt

Nucleotide repeat sequences are prevalent in the genome and expansion of these sequences is associated with more than 40 neuromuscular disorders. To understand the pathogenic mechanisms underlying RNA-repeat toxicity, we performed a genetic screen in a Caenorhabditis elegans model expressing an expanded CUG repeat specifically in the muscle. Here, we show that expression of this RNA repeat impairs motility by mit...

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Literature Corpus work: 1d302c50-cf71-5440-a7ef-7701c1b717b3
DOI: 10.1101/2021.09.24.461665

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