Article
Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma.
Genes & development - 1 Jan 2017
Falletta Paola, Sanchez-Del-Campo Luis, Chauhan Jagat, Effern Maike, Kenyon Amy, Kershaw Christopher J, Siddaway Robert, Lisle Richard, Freter Rasmus, Daniels Matthew J, Lu Xin, Tüting Thomas, Middleton Mark, Buffa Francesca M, Willis Anne E, Pavitt Graham, Ronai Ze'ev A, Sauka-Spengler Tatjana, Hölzel Michael, Goding Colin R
Abstract excerpt
The intratumor microenvironment generates phenotypically distinct but interconvertible malignant cell subpopulations that fuel metastatic spread and therapeutic resistance. Whether different microenvironmental cues impose invasive or therapy-resistant phenotypes via a common mechanism is unknown. In melanoma, low expression of the lineage survival oncogene microphthalmia-associated transcription factor (MITF)...
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