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Article

The complex relationship between MITF and the immune system: a Melanoma ImmunoTherapy (response) Factor?

1 Dec 2020

Abstract excerpt

The clinical benefit of immune checkpoint inhibitory therapy (ICT) in advanced melanomas is limited by primary and acquired resistance. The molecular determinants of the resistance have been extensively studied, but these discoveries have not yet been translated into therapeutic benefits. As such, a paradigm shift in melanoma treatment, to surmount the therapeutic impasses linked to the resistance, is an...

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PMID: 33276788
DOI: 10.1186/s12943-020-01290-7

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