Article

Membrane-Localized Mutations Predict the Efficacy of Cancer Immunotherapy

2022-05-29

Abstract excerpt

<h4>ABSTRACT</h4> Due to their genetic instability, tumor cells bear mutations that can effectively be recognized by the immune system. In the clinic, immune checkpoint immunotherapy (ICI) can re-activate immune reactions against mutated proteins, known as neoantigens, leading to remarkable remission in cancer patients. Nevertheless, only a minority of patients are responsive to ICI, and approaches for prediction...

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Literature Corpus work: 6400620a-d9cd-593e-b49f-758e55cf394b
DOI: 10.1101/2022.05.28.22275728

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