Article

Selective targeting of Mnk2 Drives Proteomic Rewiring of Tumor-Associated Macrophages to Restore Antitumor Immunity and suppress tumor progression

2026-06-23

Abstract excerpt

<title>Abstract</title> <p>Tumor-associated macrophages (TAMs) are major regulators of the tumor immune microenvironment and are frequently associated with poor clinical outcomes. Although TAMs often acquire immunosuppressive phenotypes in established tumors, they retain substantial plasticity and can be reprogrammed toward immunostimulatory states. The molecular mechanisms controlling these transitions remain in...

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Literature Corpus work: 0a9e54c9-416c-5901-a902-97def6e1787c
DOI: 10.21203/rs.3.rs-9986382/v1

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