Article

Spatial transcriptomics analysis identifies a unique tumor-promoting function of the meningeal stroma in melanoma leptomeningeal disease

2023-12-19

Abstract excerpt

<h4>ABSTRACT</h4> Leptomeningeal disease (LMD) remains a rapidly lethal complication for late-stage melanoma patients. The inaccessible nature of the disease site and lack of understanding of the biology of this unique metastatic site are major barriers to developing efficacious therapies for patients with melanoma LMD. Here, we characterize the tumor microenvironment of the leptomeningeal tissues and patient-mat...

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Literature Corpus work: 72345d15-2463-5849-88c7-9da94b37ebb1
DOI: 10.1101/2023.12.18.572266

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Spatial transcriptomics analysis identifies a unique tumor-promoting function of the meningeal stroma in melanoma leptomeningeal diseaseDOI 10.1101/2023.12.18.572266Read

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