Article

TREX1 restricts CRISPR-Cas9 genome editing in human cells

2022-12-13

Abstract excerpt

CRISPR-Cas mediated homology-directed repair (HDR) can flexibly introduce desired mutations at targeted sites in a genome. But achieving high HDR efficiencies is a major hurdle in many cellular contexts. Moreover, cells from patients with mutations in DNA repair factors can exhibit low CRISPR-Cas-mediated HDR, complicating genome editing as a potential treatment. We used genome-wide screening in Fanconi anemia (FA...

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Literature Corpus work: e1c69ce5-c954-53b5-b268-9a2e3f221b97
DOI: 10.1101/2022.12.12.520063

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