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Article

Identification of the <i>Meg1</i> / <i>Grb10</i> imprinted gene on mouse proximal chromosome 11, a candidate for the Silver–Russell syndrome gene

3 Feb 1998

Abstract excerpt

In a systematic screen for maternally expressed imprinted genes using subtraction hybridization with androgenetic and normal fertilized mouse embryos, seven candidate maternally expressed genes (Megs) have been isolated, including the H19 and p57(Kip2) genes that are known to be maternally expressed. Herein, we demonstrate that an imprinted gene, Meg1, is apparently identical to Grb10 (growth factor...

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Share to Epigenetics and DNA Methylation
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PMID: 9448292
DOI: 10.1073/pnas.95.3.1102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of the <i>Meg1</i> / <i>Grb10</i> imprinted gene on mouse proximal chromosome 11, a candidate for the Silver–Russell syndrome genePMID 9448292Read ↗

Paternal deletion of Meg1/Grb10 DMR causes maternalization of the Meg1/Grb10 cluster in mouse proximal Chromosome 11 leading to severe pre- and postnatal growth retardationSemantic proximity Read ↗

Identification of an imprinted gene, <i>Meg3</i>/<i>Gtl2</i> and its human homologue <i>MEG3</i>, first mapped on mouse distal chromosome 12 and human chromosome 14qSemantic proximity Read ↗

Conserved methylation imprints in the human and mouse GRB10 genes with divergent allelic expression suggests differential reading of the same markSemantic proximity Read ↗

Maternal repression of the human GRB10 gene in the developing central nervous system; evaluation of the role for GRB10 in Silver-Russell syndrome.Semantic proximity Read ↗

Imprinting regulation of the murine Meg1/Grb10 and human GRB10 genes; roles of brain-specific promoters and mouse-specific CTCF-binding sites.Semantic proximity Read ↗

Imprinted <i>Grb10</i> , encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor ( <i>Igf1r</i> ) and insulin receptor ( <i>Insr</i> ) genesSemantic proximity Read ↗

At Least Ten Genes Define the Imprinted Dlk1-Dio3 Cluster on Mouse Chromosome 12qF1Semantic proximity Read ↗

Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism.Semantic proximity Read ↗

Mouse <i>Peg9/Dlk1</i> and human <i>PEG9/DLK1</i> are paternally expressed imprinted genes closely located to the maternally expressed imprinted genes: mouse <i>Meg3/Gtl2</i> and human <i>MEG3</i>Semantic proximity Read ↗

Human GRB10 is imprinted and expressed from the paternal and maternal allele in a highly tissue- and isoform-specific fashion.Semantic proximity Read ↗

Imprinting of human GRB10 and its mutations in two patients with Russell-Silver syndrome.Semantic proximity Read ↗

Identification of Grf1 on mouse chromosome 9 as an imprinted gene by RLGS–MSemantic proximity Read ↗

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