Imprint switch mutations at Rasgrf1 support conflict hypothesis of imprinting and define a growth control mechanism upstream of IGF1.

Abstract excerpt

Rasgrf1 is imprinted and expressed preferentially from the paternal allele in neonatal mouse brain. At weaning, expression becomes biallelic. Using a mouse model, we assayed the effects of perturbing imprinted Rasgrf1 expression in mice with the following imprinted expression patterns: monoallelic paternal (wild type), monoallelic maternal (maternal only), biallelic (both alleles transcribed), and null (neither...

Topics

• Animals
• Body Size
• Female
• Gene Expression Regulation, Developmental
• Genomic Imprinting
• Insulin-Like Growth Factor I
• Male
• Mice
• Mice, Inbred C57BL
• Mutation
• ras-GRF1