Article

Resistin-like Molecule β Acts as a Mitogenic Factor in Hypoxic Pulmonary Hypertension via the Ca2+-dependent PI3K/Akt/mTOR and PKC/MAPK Signaling Pathways

2020-12-04

Abstract excerpt

<title>Abstract</title> <p><bold>BACKGROUND:</bold> Pulmonary arterial smooth muscle cell (PASMC) proliferation plays a crucial role in hypoxia-induced pulmonary hypertension (HPH). Previous studies have found that resistin-like molecule β (RELM-β) is upregulated <italic>de novo</italic> in response to hypoxia in cultured human PASMCs (hPASMCs). RELM-β has been reported to promote hPASMC proliferation and is invo...

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Literature Corpus work: e18c1304-7fef-5a1c-be83-2f886191eea4
DOI: 10.21203/rs.3.rs-50645/v3

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