Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PTBP1 Targets ILK to Regulate the Hypoxia-Induced Phenotypic Transformation of Pulmonary Artery Smooth Muscle Cells.

Drug design, development and therapy - 1 Jan 2021

Yan Gaoliang, Sun Renhua, Chen Zhongpu, Pan Xiaodong, Sheng Zulong, Tang Chengchun

Abstract excerpt

PURPOSE: Pulmonary hypertension (PH) is a pathological process mainly characterized by the progressive increase in pulmonary vascular resistance. The degradation of pulmonary artery smooth muscle cells (PASMCs) from contractile/differentiated phenotype to synthetic/dedifferentiated phenotype is a key factor for hypoxic pulmonary hypertension. MATERIALS AND METHODS: In this study, qPCR was performed to evaluate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Hypoxia
Share to Gene Knockdown Techniques

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Heterogeneous-Nuclear Ribonucleoproteins

Share to Hypertension, Pulmonary

Share to Myocytes, Smooth Muscle

Share to Polypyrimidine Tract-Binding Protein

Share to Pulmonary Artery

Share to Rats, Sprague-Dawley

Source

Open in PubMed Open full text

Identifiers

PMID: 34012255
DOI: 10.2147/DDDT.S275000
PMCID: PMC8128346

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PTBP1 Targets ILK to Regulate the Hypoxia-Induced Phenotypic Transformation of Pulmonary Artery Smooth Muscle Cells.PMID 34012255Read ↗

MiR-20a regulates the PRKG1 gene by targeting its coding region in pulmonary arterial smooth muscle cells.Semantic proximity Read ↗

Role of MiR‐542‐3p/Integrin‐Linked Kinase/Myocardin Signaling Axis in Hypoxic Pulmonary HypertensionSemantic proximity Read ↗

Research progress on the mechanism of phenotypic transformation of pulmonary artery smooth muscle cells induced by hypoxiaSemantic proximity Read ↗

QKI Promotes Hypoxia Induced Smooth Muscle Reprogramming in Pulmonary HypertensionSemantic proximity Read ↗

Long non-coding RNA PVT1 promotes proliferation and migration of pulmonary smooth muscle cells in pulmonary arterial hypertension through miR-140-5p/Fxr1 axisSemantic proximity Read ↗

CircLMBR1 inhibits phenotypic transformation of hypoxia-induced pulmonary artery smooth muscle via the splicing factor PUF60.Semantic proximity Read ↗

PINK1-mediated Mitophagy Contributes to Pulmonary Vascular Remodeling in Pulmonary HypertensionSemantic proximity Read ↗

Exploring the pathogenesis of pulmonary vascular diseaseSemantic proximity Read ↗

Overexpressed lncRNA AC068039.4 contributes to proliferation and cell cycle progression of pulmonary artery smooth muscle cells via sponging miR-26a-5p/TRPC6 in hypoxic pulmonary arterial hypertensionSemantic proximity Read ↗

Updated perspective of EPAS1 and the role in pulmonary hypertensionSemantic proximity Read ↗

PTPN1 deficiency modulates BMPR2 signaling and induces endothelial dysfunction in Pulmonary Arterial HypertensionSemantic proximity Read ↗

MiR-449a-5p mediates mitochondrial dysfunction and phenotypic transition by targeting Myc in pulmonary arterial smooth muscle cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.