Article
PTBP1 Targets ILK to Regulate the Hypoxia-Induced Phenotypic Transformation of Pulmonary Artery Smooth Muscle Cells.
Drug design, development and therapy - 1 Jan 2021
Yan Gaoliang, Sun Renhua, Chen Zhongpu, Pan Xiaodong, Sheng Zulong, Tang Chengchun
Abstract excerpt
PURPOSE: Pulmonary hypertension (PH) is a pathological process mainly characterized by the progressive increase in pulmonary vascular resistance. The degradation of pulmonary artery smooth muscle cells (PASMCs) from contractile/differentiated phenotype to synthetic/dedifferentiated phenotype is a key factor for hypoxic pulmonary hypertension. MATERIALS AND METHODS: In this study, qPCR was performed to evaluate...
Topics
- Animals
- Cell Hypoxia
- Down-Regulation
- Gene Expression Regulation
- Gene Knockdown Techniques
- Heterogeneous-Nuclear Ribonucleoproteins
- Hypertension, Pulmonary
- Male
- Myocytes, Smooth Muscle
- Phenotype