Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deletion of LR11 Attenuates Hypoxia-Induced Pulmonary Arterial Smooth Muscle Cell Proliferation With Medial Thickening in Mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2016

Jiang Le, Konishi Hakuoh, Nurwidya Fariz, Satoh Kimio, Takahashi Fumiyuki, Ebinuma Hiroyuki, Fujimura Kengo, Takasu Kiyoshi, Jiang Meizi, Shimokawa Hiroaki, Bujo Hideaki, Daida Hiroyuki

Abstract excerpt

OBJECTIVE: We aimed to determine whether LR11 (low-density lipoprotein receptor with 11 binding repeats) is a potential key regulator of smooth muscle cell (SMC) proliferation during the progression of hypoxia-induced medial thickening in mice and whether sLR11 (soluble LR11) can serve as a biomarker in patients with pulmonary arterial hypertension. APPROACH AND RESULTS: The role of LR11 in pulmonary arterial...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arterial Pressure
Share to Hypertension, Pulmonary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to LDL-Receptor Related Proteins

Share to Neointima

Share to Pulmonary Artery

Share to Vascular Remodeling

Share to Vascular Resistance

Share to Ventricular Function, Right

Source

Identifiers

PMID: 27493099
DOI: 10.1161/ATVBAHA.116.307900

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deletion of LR11 Attenuates Hypoxia-Induced Pulmonary Arterial Smooth Muscle Cell Proliferation With Medial Thickening in Mice.PMID 27493099Read ↗

Targeting Macrophage Crosstalk to PASMC by Blunting Inflammatory Phenotype Via SerpinB1 Protects Against Hypoxia-Induced Pulmonary Hypertension.Semantic proximity Read ↗

Phenotypic Diversity of Vascular Smooth Muscle Cells in Pulmonary Arterial Hypertension: Implications for Therapy.Semantic proximity Read ↗

Resistin-like Molecule β Acts as a Mitogenic Factor in Hypoxic Pulmonary Hypertension via the Ca2+-dependent PI3K/Akt/mTOR and PKC/MAPK Signaling PathwaysSemantic proximity Read ↗

Regulatory mechanisms in multiple vascular diseases locus <i>LRP1</i> involve repression by SNAIL and extracellular matrix remodelingSemantic proximity Read ↗

Factors Associated with Heritable Pulmonary Arterial Hypertension Exert Convergent Actions on the miR-130/301-Vascular Matrix Feedback Loop.Semantic proximity Read ↗

Vascular Proteomics Reveal Novel Proteins Involved in SMC Phenotypic Change: OLR1 as a SMC Receptor Regulating Proliferation and Inflammatory Response.Semantic proximity Read ↗

LOX-1 mediated phenotypic switching of pulmonary arterial smooth muscle cells contributes to hypoxic pulmonary hypertension.Semantic proximity Read ↗

KLF6 activation marks an angiogenic and apoptosis resistant endothelial phenotype in pulmonary arterial hypertension.Semantic proximity Read ↗

Remodelling of the endothelial extracellular matrix promotes smooth muscle cell hyperplasia in pulmonary hypertension due to left heart disease.Semantic proximity Read ↗

VEGF receptor promotes hypoxia-induced hematopoietic progenitor proliferation and differentiationSemantic proximity Read ↗

Phenotypically Silent Bone Morphogenetic Protein Receptor 2 Mutations Predispose Rats to Inflammation-Induced Pulmonary Arterial Hypertension by Enhancing the Risk for Neointimal TransformationSemantic proximity Read ↗

TCF7L2 (Transcription Factor 7-Like 2) Regulation of GATA6 (GATA-Binding Protein 6)-Dependent and -Independent Vascular Smooth Muscle Cell Plasticity and Intimal HyperplasiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.