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Article

Gene expression profiling of common signal transduction pathways affected by rBMSCs/F92A-Cav1 in the lungs of rat with pulmonary arterial hypertension.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Oct 2016

Chen Haiying, Yang Hongli, Xu Chong, Yue Hongmei, Xia Peng, Strappe Pádraig Michael, Wang Lei, Pan Li, Tang Wenqiang, Chen Shuangfeng, Wang Lexin

Abstract excerpt

BACKGROUND: Pulmonary arterial hypertension (PAH) is associated with sustained vasoconstriction, inflammation and suppressed apoptosis of smooth muscle cells. Our previous studies have found that rat bone marrow-derived mesenchymal stem cells (rBMSCs) transduced with a mutant caveolin-1(F92A-Cav1) could enhance endothelial nitric oxide synthase (eNOS) activity and improve pulmonary vascular remodeling, but the...

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PMID: 27470556
DOI: 10.1016/j.biopha.2016.06.028

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PAH
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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