Article

Temporal Changes in Key Signal Transduction Pathways Mediating Muscle Protein Synthesis with Adaptive and Maladaptive Right Ventricular Hypertrophy in Pulmonary Arterial Hypertension

2021-12-10

Abstract excerpt

<title>Abstract</title> <p>BackgroundPulmonary Arterial Hypertension (PAH) is a progressive cardiopulmonary disease and is characterized by occlusive remodeling of pulmonary arterioles and increased pulmonary vascular resistance. With the onset of PAH, the right ventricle (RV) of the heart adapts to the increased afterload pressure by undergoing adaptive hypertrophic remodeling to maintain adequate blood flow. Ho...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 465015d5-df19-5ef2-817c-ff33cac52c88
DOI: 10.21203/rs.3.rs-1047703/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Temporal Changes in Key Signal Transduction Pathways Mediating Muscle Protein Synthesis with Adaptive and Maladaptive Right Ventricular Hypertrophy in Pulmonary Arterial HypertensionDOI 10.21203/rs.3.rs-1047703/v1Read

Dynamic microRNA expression during the transition from right ventricular hypertrophy to failureSemantic proximity Read

Molecular Signature of a Right Heart Failure Program in Chronic Severe Pulmonary HypertensionSemantic proximity Read

Resistin-like Molecule β Acts as a Mitogenic Factor in Hypoxic Pulmonary Hypertension via the Ca2+-dependent PI3K/Akt/mTOR and PKC/MAPK Signaling PathwaysSemantic proximity Read

Extracellular Matrix Instability and Chronic Inflammation Underlie Maladaptive Right Ventricular Pressure Overload Remodeling and Failure in Male MiceSemantic proximity Read

Multimodality Molecular Profiling Nominates Targetable Mechanisms in Progressive RV DysfunctionSemantic proximity Read

Signaling mechanisms in thyroid hormone-induced cardiac hypertrophy.Semantic proximity Read

A common gene signature of the right ventricle in failing rat and human heartsSemantic proximity Read

A Multi-omic and Multi-Species Analysis of Right Ventricular FailureSemantic proximity Read

Targeted Proteomics of Right Heart Adaptation to Pulmonary Arterial HypertensionSemantic proximity Read

Transcriptomic Signature of Right Ventricular Failure in Experimental Pulmonary Arterial Hypertension: Deep Sequencing Demonstrates Mitochondrial, Fibrotic, Inflammatory and Angiogenic AbnormalitiesSemantic proximity Read

Chronic carvedilol treatment partially reverses the right ventricular failure transcriptional profile in experimental pulmonary hypertensionSemantic proximity Read

Glycoprotein 130 Antagonism Counteracts Metabolic and Inflammatory Alterations to Enhance Right Ventricle Function in Pulmonary Artery Banded PigsSemantic proximity Read