Chemical N-degrons activate p62-mediated mitophagy to alleviate mitochondrial neuropathies

Abstract excerpt

Pharmacological activation of mitophagy offers a promising strategy to eliminate dysfunctional mitochondria. We previously identified the autophagy receptor p62/SQSTM1 as an N-recognin whose activity is enhanced by Arg/N-degrons. Here, we show that Arg/N-degrons generated by ATE1 -encoded R-transferase regulate p62-mediated mitophagy by promoting its recruitment to damaged mitochondria. Structural modification of...

Topics

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• ATP Synthase and ATPases Research
• Autophagy in Disease and Therapy
• Berberine and alkaloids research
• Biological Products
• Disease
• Drug Therapy
• Mitochondrial Function and Pathology
• Natural Antidiabetic Agents Studies

Identifiers and source

Literature Corpus work

e181d32b-2c57-5f16-9e29-80a986bda2c0

DOI

10.64898/2026.02.19.706908