Article

Discovery of a molecular glue that enhances UPR <sup>mt</sup> to restore proteostasis <i>via</i> TRKA-GRB2-EVI1-CRLS1 axis

2021-02-17

Abstract excerpt

Lowering proteotoxicity is a potentially powerful approach for the treatment of neurological disorders, such as Parkinson’s disease. The unfolded protein response (UPR) is a major mechanism that preserves the network maintaining cellular proteostasis. In the present study, we developed the screening strategy to discover compounds that significantly enhanced the activation of mitochondrial UPR (UPR mt ) through in...

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Literature Corpus work: e8e89da0-a526-56c5-9607-a8ee185eaf2a
DOI: 10.1101/2021.02.17.431525

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