Article

Epicoccin A Ameliorates PD-Like Symptoms in Zebrafish: Enhancement of PINK1/Parkin-Dependent Mitophagy and Inhibition of Excessive Oxidative Stress

2025-03-14

Abstract excerpt

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder, yet effective agents for its prevention and therapy remain highly limited. Epicoccin A, a significant secondary metabolite from Exserohilum sp., demonstrates various biological activities, however, its neuroprotective effects have not been elucidated. Here, we investigated the therapeutic potential of epicoccin A for PD by evaluating...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 74f2b732-467c-55ac-8703-de9421efd677
DOI: 10.20944/preprints202503.1021.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Epicoccin A Ameliorates PD-Like Symptoms in Zebrafish: Enhancement of PINK1/Parkin-Dependent Mitophagy and Inhibition of Excessive Oxidative StressDOI 10.20944/preprints202503.1021.v1Read

Mitochondrial dysfunction-targeting therapeutics of natural products in Parkinson’s diseaseSemantic proximity Read

The alleviative effect of Calendula officinalis L. extract against Parkinson’s disease-like pathology in zebrafish via the involvement of autophagy activationSemantic proximity Read

Targeting PINK1 Using Natural Products for the Treatment of Human Diseases.Semantic proximity Read

Regulation of mitophagy and mitochondrial function: Natural compounds as potential therapeutic strategies for Parkinson's diseaseSemantic proximity Read

Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathwaySemantic proximity Read

Berberine extends healthspan and delays neurodegenerative diseases in Caenorhabditis elegans through ROS-dependent PMK-1/SKN-1 activationSemantic proximity Read

Neuroprotective Effect of the Marine-Derived Compound 11-Dehydrosinulariolide through DJ-1-Related Pathway in In Vitro and In Vivo Models of Parkinson’s DiseaseSemantic proximity Read

The potential applications of traditional Chinese medicine in Parkinson's disease: A new opportunitySemantic proximity Read

Rosmarinic acid ameliorated oxidative stress, neuronal injuries, and mitochondrial dysfunctions mediated by polyglutamine and ɑ-synuclein in Caenorhabditis elegans modelsSemantic proximity Read

Oxidative Stress Mechanisms Underlying Parkinson’s Disease-Associated Neurodegeneration in C. elegansSemantic proximity Read

Identification of structural features of selected flavonoids responsible for neuroprotection using a <i>Drosophila</i> model of Parkinson’s diseaseSemantic proximity Read

Target oxidative stress-induced disulfidptosis: novel therapeutic avenues in Parkinson’s diseaseSemantic proximity Read