Article

Activation of pro-survival autophagy by a small molecule promoting p62 oligomerisation

2025-05-29

Abstract excerpt

Autophagy is a critical mechanism of cellular quality control, orchestrated by selective autophagy receptor (SAR) proteins. Pharmacologically enhancing the cargo-targeting capacity of SARs presents an attractive but underexplored strategy for the precise therapeutic activation of autophagy. Here, we characterise SQ-1, a small-molecule activator of autophagy that targets the prototypical SAR protein p62/SQSTM1 (seq...

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Literature Corpus work: 2dac97b8-9fea-58ed-ae6c-e8a3988cae9f
DOI: 10.1101/2025.05.27.656309

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