Targeting PINK1 Using Natural Products for the Treatment of Human Diseases.

doi:10.1155/2021/4045819

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Article

Targeting PINK1 Using Natural Products for the Treatment of Human Diseases.

BioMed research international - 1 Jan 2021

Li Yan-Qin, Zhang Fan, Yu Li-Ping, Mu Jian-Kang, Yang Ya-Qin, Yu Jie, Yang Xing-Xin

Abstract excerpt

PINK1, also known as PARK6, is a PTEN-induced putative kinase 1 that is encoded by nuclear genes. PINK1 is ubiquitously expressed and regulates mitochondrial function and mitophagy in a range of cell types. The dysregulation of PINK1 is associated with the pathogenesis and development of mitochondrial-associated disorders. Many natural products could regulate PINK1 to relieve PINK1-associated diseases. Here, we...

Topics

Animals
Biological Products
Disease
Drug Therapy
Humans
Mitochondria
Mitochondrial Diseases
Mitophagy
Mutation
Protein Kinases
Ubiquitin-Protein Ligases
PTEN-Induced Putative Kinase

Source

Open in PubMed Open full text

Identifiers

PMID: 34751247
DOI: 10.1155/2021/4045819
PMCID: PMC8572127

Genes

PINK1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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