Article

δ-catenin haploinsufficiency is sufficient to alter behaviors and glutamatergic synapses in mice

2025-08-12

Abstract excerpt

δ-catenin (also known as CTNND2) functions as an anchor for the glutamatergic AMPA receptor (AMPARs) to regulate synaptic activity in excitatory synapses. Alteration in the gene coding δ-catenin has been implicated in many neurological disorders. Some of these genetic alterations exhibit a profound loss of δ-catenin functions in excitatory synapses. We have shown that δ-catenin deficiency induced by the homozygous...

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Literature Corpus work: e169eb6e-ae33-544f-a121-abbe3e836298
DOI: 10.1101/2025.08.12.669907

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