Article
DIXDC1 contributes to psychiatric susceptibility by regulating dendritic spine and glutamatergic synapse density via GSK3 and Wnt/β-catenin signaling.
Molecular psychiatry - 1 Feb 2018
Martin P-M, Stanley R E, Ross A P, Freitas A E, Moyer C E, Brumback A C, Iafrati J, Stapornwongkul K S, Dominguez S, Kivimäe S, Mulligan K A, Pirooznia M, McCombie W R, Potash J B, Zandi P P, Purcell S M, Sanders S J, Zuo Y, Sohal V S, Cheyette B N R
Abstract excerpt
Mice lacking DIX domain containing-1 (DIXDC1), an intracellular Wnt/β-catenin signal pathway protein, have abnormal measures of anxiety, depression and social behavior. Pyramidal neurons in these animals' brains have reduced dendritic spines and glutamatergic synapses. Treatment with lithium or a glycogen synthase kinase-3 (GSK3) inhibitor corrects behavioral and neurodevelopmental phenotypes in these animals....
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