Article

The autism-associated loss of δ-catenin functions disrupts social behaviors

2023-01-13

Abstract excerpt

δ-catenin is expressed in excitatory synapses and functions as an anchor for the glutamatergic AMPA receptor (AMPAR) GluA2 subunit in the postsynaptic density. The glycine 34 to serine (G34S) mutation in the δ-catenin gene is found in autism spectrum disorder (ASD) patients and induces loss of δ-catenin functions at excitatory synapses, which is presumed to underlie ASD pathogenesis in humans. However, how the G3...

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Literature Corpus work: 77c8240f-4d3d-57c5-9bbd-53571f5f2fb7
DOI: 10.1101/2023.01.12.523372

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