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Article

GABAergic deficits and schizophrenia-like behaviors in a mouse model carrying patient-derived neuroligin-2 R215H mutation.

Molecular brain - 1 Jun 2018

Jiang Dong-Yun, Wu Zheng, Forsyth Cody Tieu, Hu Yi, Yee Siu-Pok, Chen Gong

Abstract excerpt

Schizophrenia (SCZ) is a severe mental disorder characterized by delusion, hallucination, and cognitive deficits. We have previously identified from schizophrenia patients a loss-of-function mutation Arg215→His215 (R215H) of neuroligin 2 (NLGN2) gene, which encodes a cell adhesion molecule critical for GABAergic synapse formation and function. Here, we generated a novel transgenic mouse line with neuroligin-2...

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Source

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Identifiers

PMID: 29859117
DOI: 10.1186/s13041-018-0375-6
PMCID: PMC5984814

Genes

NLGN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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