Article
S-SCAM, a rare copy number variation gene, induces schizophrenia-related endophenotypes in transgenic mouse model.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 4 Feb 2015
Zhang Nanyan, Zhong Peng, Shin Seung Min, Metallo Jacob, Danielson Eric, Olsen Christopher M, Liu Qing-song, Lee Sang H
Abstract excerpt
Accumulating genetic evidence suggests that schizophrenia (SZ) is associated with individually rare copy number variations (CNVs) of diverse genes, often specific to single cases. However, the causality of these rare mutations remains unknown. One of the rare CNVs found in SZ cohorts is the duplication of Synaptic Scaffolding Molecule (S-SCAM, also called MAGI-2), which encodes a postsynaptic scaffolding protein...
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