Article

Formation of amyloid loops in brain tissues is controlled by the flexibility of protofibril chains

2022-09-13

Abstract excerpt

<h4>ABSTRACT</h4> Neurodegenerative diseases, such as Alzheimer’s Disease (AD), are associated with protein misfolding and aggregation into amyloid fibrils. Increasing evidence suggests that soluble, low molecular weight aggregates play a key role in disease-associated toxicity. Within these aggregates, protofibrillar loop-like structures have been observed for a variety of amyloid systems and their presence in b...

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Literature Corpus work: e169d5e4-a280-5852-86fe-2a683491b267
DOI: 10.1101/2022.09.13.507729

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