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Quantification of amyloid fibril polymorphism by nano-morphometry reveals the individuality of filament assembly

11 Sept 2020

Abstract excerpt

Amyloid fibrils are highly polymorphic structures formed by many different proteins. They provide biological function but also abnormally accumulate in numerous human diseases. The physicochemical principles of amyloid polymorphism are not understood due to lack of structural insights at the single-fibril level. To identify and classify different fibril polymorphs and to quantify the level of heterogeneity is...

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PMID: 36703355
DOI: 10.1038/s42004-020-00372-3

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