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Article

Coexistence of ribbon and helical fibrils originating from hIAPP(20-29) revealed by quantitative nanomechanical atomic force microscopy.

Proceedings of the National Academy of Sciences of the United States of America - 19 Feb 2013

Zhang Shuai, Andreasen Maria, Nielsen Jakob T, Liu Lei, Nielsen Erik H, Song Jie, Ji Gang, Sun Fei, Skrydstrup Troels, Besenbacher Flemming, Nielsen Niels C, Otzen Daniel E, Dong Mingdong

Abstract excerpt

Uncontrolled misfolding of proteins leading to the formation of amyloid deposits is associated with more than 40 types of diseases, such as neurodegenerative diseases and type-2 diabetes. These irreversible amyloid fibrils typically assemble in distinct stages. Transitions among the various intermediate stages are the subject of many studies but are not yet fully elucidated. Here, we combine high-resolution...

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Identifiers

PMID: 23388629
DOI: 10.1073/pnas.1209955110
PMCID: PMC3581879

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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