Article
Distal amyloid β-protein fragments template amyloid assembly.
Protein science : a publication of the Protein Society - 1 Jul 2018
Do Thanh D, Sangwan Smriti, de Almeida Natália E C, Ilitchev Alexandre I, Giammona Maxwell, Sawaya Michael R, Buratto Steven K, Eisenberg David S, Bowers Michael T
Abstract excerpt
Amyloid formation is associated with devastating diseases such as Alzheimer's, Parkinson's and Type-2 diabetes. The large amyloid deposits found in patients suffering from these diseases have remained difficult to probe by structural means. Recent NMR models also predict heterotypic interactions from distinct peptide fragments but limited evidence of heterotypic packed sheets is observed in solution. Here we...
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