Article

IRE1α regulates macrophage polarization, PD-L1 expression and tumor survival

2020-02-17

Abstract excerpt

<h4>ABSTRACT</h4> In the tumor microenvironment local immune dysregulation is driven in part by macrophages and dendritic cells that are polarized to a mixed proinflammatory/immune suppressive phenotype. The unfolded protein response (UPR) is emerging as the possible origin of these events. Here we report that the inositol-requiring enzyme 1 (IRE1α) branch of the UPR is directly involved in the polarization of ma...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e1581715-0e26-515a-8c38-b84df6f5cb78
DOI: 10.1101/2020.02.17.952457

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

IRE1α regulates macrophage polarization, PD-L1 expression and tumor survivalDOI 10.1101/2020.02.17.952457Read

IRE1α regulates macrophage polarization, PD-L1 expression, and tumor survival.Semantic proximity Read

Targeting IRE1α reprograms the tumor microenvironment and enhances anti-tumor immunity in prostate cancerSemantic proximity Read

The multiple roles of the unfolded protein response regulator IRE1α in cancerSemantic proximity Read

The UPR Transducer IRE1 Promotes Breast Cancer Malignancy by Degrading Tumor Suppressor microRNAsSemantic proximity Read

The Caspase-1-EGR4 axis drives acute myeloid leukemia progression by orchestrating macrophage repolarizationSemantic proximity Read

Host-derived Interleukin 1α induces an immunosuppressive tumor microenvironment via regulating monocyte-to-macrophage differentiationSemantic proximity Read

A Human Genome-Wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1α–XBP1 ActivationSemantic proximity Read

Interleukin-34-orchestrated tumor-associated macrophage reprogramming is required for tumor immune escape driven by p53 inactivationSemantic proximity Read

Signal regulatory protein α is associated with tumor-polarized macrophages phenotype switch and plays a pivotal role in tumor progression.Semantic proximity Read

The unfolded-protein-response sensor IRE-1α regulates the function of CD8α+ dendritic cellsSemantic proximity Read

S1P/S1PR1 signaling couples mitochondrial Ca²⁺-dependent cytoskeletal remodeling to IL-6/IL-33-driven macrophage polarization in breast cancerSemantic proximity Read

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophagesSemantic proximity Read