Article
Signal regulatory protein α is associated with tumor-polarized macrophages phenotype switch and plays a pivotal role in tumor progression.
Hepatology (Baltimore, Md.) - 1 Aug 2013
Pan Yu-fei, Tan Ye-xiong, Wang Min, Zhang Jian, Zhang Bo, Yang Chun, Ding Zhi-wen, Dong Li-wei, Wang Hong-yang
Abstract excerpt
UNLABELLED: Macrophages (Mψ) are the major component of infiltrating leukocytes in tumors and exhibit distinct phenotypes according to the microenvironment. We have recently found that signal regulatory protein α (SIRPα), the inhibitory molecule expressed on myeloid cells, plays a critical role in controlling innate immune activation. Here, we identify that SIRPα is down-regulated on monocytes/Mψ isolated from...
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