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Interleukin-34-orchestrated tumor-associated macrophage reprogramming is required for tumor immune escape driven by p53 inactivation

24 Sept 2024

Abstract excerpt

T cell-mediated antitumor immunity to promote immune escape. Blockade of the IL-34-CD36 axis elicited antitumor immunity and synergized with anti-PD-1 immunotherapy, leading to a complete response. Our findings reveal the underlying mechanism of p53 modulation of the tumor immune microenvironment and provide a potential target for immunotherapy of cancer with p53 inactivation.

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PMID: 39321806
DOI: 10.1016/j.immuni.2024.08.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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