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Article

IRE1α regulates macrophage polarization, PD-L1 expression, and tumor survival.

PLoS biology - 1 Jun 2020

Batista Alyssa, Rodvold Jeffrey J, Xian Su, Searles Stephen C, Lew Alyssa, Iwawaki Takao, Almanza Gonzalo, Waller T Cameron, Lin Jonathan, Jepsen Kristen, Carter Hannah, Zanetti Maurizio

Abstract excerpt

In the tumor microenvironment, local immune dysregulation is driven in part by macrophages and dendritic cells that are polarized to a mixed proinflammatory/immune-suppressive phenotype. The unfolded protein response (UPR) is emerging as the possible origin of these events. Here we report that the inositol-requiring enzyme 1 (IRE1α) branch of the UPR is directly involved in the polarization of macrophages in...

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Identifiers

PMID: 32520957
DOI: 10.1371/journal.pbio.3000687
PMCID: PMC7307794

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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