Article

The Caspase-1-EGR4 axis drives acute myeloid leukemia progression by orchestrating macrophage repolarization

2026-01-08

Abstract excerpt

<title>Abstract</title> <p>The polarization of tumor-associated macrophages (TAMs) toward an M2-like phenotype critically promotes acute myeloid leukemia (AML) progression. Building on the clinical observation that Caspase-1 (CASP1) expression is elevated in AML and correlates with M2 macrophage abundance, we identify a novel signaling axis in AML cells, involving CASP1 and the transcription factor early growth r...

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Literature Corpus work: b5fdc830-eda6-5dd4-8c28-491cc7695430
DOI: 10.21203/rs.3.rs-8429347/v1

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