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MELK inhibition effectively suppresses growth of glioblastoma and cancer stem-like cells by blocking AKT and FOXM1 pathways

2020-05-07

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Glioblastoma multiforme (GBM) is a devastating disease yet no effective drug treatment has been established to date. Glioblastoma stem-like cells (GSCs) are insensitive to treatment and may be one of the reasons for the relapse of GBM. Maternal embryonic leucine zipper kinase gene (<italic>MELK</italic>) plays an important role in the malignant proliferation and...

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Literature Corpus work
c7dd4e3f-08f9-5b50-8b9f-40b8dd46c361
DOI
10.21203/rs.3.rs-26425/v1
Open publication

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