Article

Cardiorenal heart failure with preserved ejection fraction is caused by a reversible rise of mineralocorticoid-induced fibroblast subtypes

2025-07-14

Abstract excerpt

<title>Abstract</title> Heart failure with preserved ejection fraction (HFpEF) is driven by co-morbidities. While specific treatments to enable recovery of HFpEF are lacking, recent clinical trials indicate beneficial effects of mineralocorticoid receptor (MR) antagonists. Here we treated mice with aldosterone-salt to incude a cardiorenal HFpEF-like phenotype and studied progression and regression of the disea...

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Literature Corpus work: e14d3b52-6042-538a-bbec-333caff7b163
DOI: 10.21203/rs.3.rs-7039115/v1

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