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Modelling genetic risk of β-cell dysfunction in human induced pluripotent stem cells from patients carrying the <i>MTNR1B</i> risk variant

2024-07-22

Abstract excerpt

Disruptions in circadian rhythm, partly controlled by the hormone melatonin, increase the risk of type 2 diabetes (T2D). Accordingly, a variant of the gene encoding the melatonin receptor 1B ( MTNR1B ) is robustly associated with increased risk of T2D. This single nucleotide polymorphism (SNP; rs10830963; G-allele) is an expression quantitative trait locus (eQTL) in human pancreatic islets, conferring increased e...

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Literature Corpus work
e1353a16-bcd9-511c-9602-4aa2419895a2
DOI
10.1101/2024.07.19.603674
Open publication

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Modelling genetic risk of β-cell dysfunction in human induced pluripotent stem cells from patients carrying the <i>MTNR1B</i> risk variantDOI 10.1101/2024.07.19.603674
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