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Article

Type 2 diabetes-associated variants of the MT2 melatonin receptor affect distinct modes of signaling.

Science signaling - 28 Aug 2018

Karamitri Angeliki, Plouffe Bianca, Bonnefond Amélie, Chen Min, Gallion Jonathan, Guillaume Jean-Luc, Hegron Alan, Boissel Mathilde, Canouil Mickaël, Langenberg Claudia, Wareham Nicholas J, Le Gouill Christian, Lukasheva Viktoria, Lichtarge Olivier, Froguel Philippe, Bouvier Michel, Jockers Ralf

Abstract excerpt

Melatonin is produced during the night and regulates sleep and circadian rhythms. Loss-of-function variants in MTNR1B, which encodes the melatonin receptor MT2, a G protein-coupled receptor (GPCR), are associated with an increased risk of type 2 diabetes (T2D). To identify specific T2D-associated signaling pathway(s), we profiled the signaling output of 40 MT2 variants by monitoring spontaneous...

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PMID: 30154102
DOI: 10.1126/scisignal.aan6622

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