Article
Genetic variants in MTNR1B affecting insulin secretion.
Annals of medicine - 1 Sept 2010
Müssig Karsten, Staiger Harald, Machicao Fausto, Häring Hans-Ulrich, Fritsche Andreas
Abstract excerpt
The incidence of type 2 diabetes mellitus has markedly increased worldwide over the past decades. Pancreatic beta-cell dysfunction as well as central and peripheral insulin resistance appears to be elementary features in the pathophysiology of type 2 diabetes mellitus. Major environmental conditions predisposing to the development of type 2 diabetes are excessive food intake and sedentary life-style on the...
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