Article
Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion.
Nature genetics - 1 Jan 2009
Lyssenko Valeriya, Nagorny Cecilia L F, Erdos Michael R, Wierup Nils, Jonsson Anna, Spégel Peter, Bugliani Marco, Saxena Richa, Fex Malin, Pulizzi Nicolo, Isomaa Bo, Tuomi Tiinamaija, Nilsson Peter, Kuusisto Johanna, Tuomilehto Jaakko, Boehnke Michael, Altshuler David, Sundler Frank, Eriksson Johan G, Jackson Anne U, Laakso Markku, Marchetti Piero, Watanabe Richard M, Mulder Hindrik, Groop Leif
Abstract excerpt
Genome-wide association studies have shown that variation in MTNR1B (melatonin receptor 1B) is associated with insulin and glucose concentrations. Here we show that the risk genotype of this SNP predicts future type 2 diabetes (T2D) in two large prospective studies. Specifically, the risk genotyp...
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