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Article

The melatonin receptor 1B gene links circadian rhythms and type 2 diabetes mellitus: an evolutionary story.

Annals of medicine - 1 Dec 2023

Zhu Hui, Zhao Zhi-Jia, Liu Hong-Yi, Cai Jie, Lu Qin-Kang, Ji Lin-Dan, Xu Jin

Abstract excerpt

Disturbed circadian rhythms have been a risk factor for type 2 diabetes mellitus (T2DM). Melatonin is the major chronobiotic hormone regulating both circadian rhythm and glucose homeostasis. The rs10830963 (G allele) of the melatonin receptor 1B (MTNR1B) gene has the strongest genetic associations with T2DM according to several genome-wide association studies. The MTNR1B rs10830963 G allele is also associated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Share to Receptor, Melatonin, MT2

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Identifiers

PMID: 36974476
DOI: 10.1080/07853890.2023.2191218
PMCID: PMC10054309

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